Summary of Conditions with Evidence
(According to the CDC, May 26, 2022)
Higher risk for severe COVID-19 outcomes is defined as an underlying medical condition or risk factor that has a published meta-analysis or systematic review or complete the CDC systematic review process. The meta-analysis or systematic review demonstrates good or strong evidence, (depending on the quality of the studies in the review or meta-analysis) for an increase in risk for at least one severe COVID-19 outcome.
Cancer
Cerebrovascular disease
Chronic kidney disease*
Chronic lung diseases limited to:
Interstitial lung disease
Pulmonary embolism
Pulmonary hypertension
Bronchiectasis
COPD (chronic obstructive pulmonary disease)
Chronic liver diseases limited to:
Cirrhosis
Non-alcoholic fatty liver disease
Alcoholic liver disease
Autoimmune hepatitis
Cystic fibrosis
Diabetes mellitus, type 1 and type 2*
Disabilities
Attention-Deficit/Hyperactivity Disorder (ADHD)
Cerebral Palsy
Congenital Malformations (Birth Defects)
Limitations with self-care or activities of daily living
Intellectual and Developmental Disabilities
Learning Disabilities
Spinal Cord Injuries
(For the list of all conditions that were part of the review, see the module below)
Heart conditions (such as heart failure, coronary artery disease, or cardiomyopathies)
HIV (human immunodeficiency virus)
Mental health disorders limited to:
Mood disorders, including depression
Schizophrenia spectrum disorders
Neurologic conditions limited to dementia
Obesity (BMI ≥30 kg/m2)*
Primary Immunodeficiencies
Pregnancy and recent pregnancy
Physical inactivity
Smoking, current and former
Solid organ or hematopoietic cell transplantation
Tuberculosis
Use of corticosteroids or other immunosuppressive medications
See List of All Disabilities from CDC’s Systematic Review Process
Suggestive higher risk for severe COVID-19 outcomes is defined as an underlying medical condition or risk factor that neither has a published meta-analysis or systematic review nor completed the CDC systematic review process. The evidence is supported by mostly cohort, case-control, or cross-sectional studies. (Systematic reviews are available for some conditions for children with underlying conditions.)
Children with certain underlying conditions
Overweight (BMI ≥25 kg/m2, but <30 kg/m2)
Sickle cell disease
Substance use disorders
Thalassemia
Mixed evidence is defined as an underlying medical condition or risk factor that has a published meta-analysis or systematic review or completing the CDC systematic review process. The meta-analysis or systematic review is inconclusive, either because the aggregated data on the association between an underlying condition and severe COVID-19 outcomes are inconsistent in direction or there are insufficient data (or limited) on the association between an underlying conditions and severe COVID-19 outcomes.
Alpha 1 antitrypsin deficiency
Asthma
Bronchopulmonary dysplasia
Hepatitis B
Hepatitis C
Hypertension*
Footnote: * indicates underlying conditions for which there is evidence for pregnant and non-pregnant people